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Journal Articles Frontiers in Bioengineering and Biotechnology Year : 2022

Toward Multiplexed Optogenetic Circuits


Owing to its ubiquity and easy availability in nature, light has been widely employed to control complex cellular behaviors. Light-sensitive proteins are the foundation to such diverse and multilevel adaptive regulations in a large range of organisms. Due to their remarkable properties and potential applications in engineered systems, exploration and engineering of natural light-sensitive proteins have significantly contributed to expand optogenetic toolboxes with tailor-made performances in synthetic genetic circuits. Progressively, more complex systems have been designed in which multiple photoreceptors, each sensing its dedicated wavelength, are combined to simultaneously coordinate cellular responses in a single cell. In this review, we highlight recent works and challenges on multiplexed optogenetic circuits in natural and engineered systems for a dynamic regulation breakthrough in biotechnological applications.
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hal-03554427 , version 1 (03-02-2022)




Ari Dwijayanti, Congqiang Zhang, Chueh Loo Poh, Thomas Lautier. Toward Multiplexed Optogenetic Circuits. Frontiers in Bioengineering and Biotechnology, 2022, 9, ⟨10.3389/fbioe.2021.804563⟩. ⟨hal-03554427⟩
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