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Journal Articles Proceedings of the National Academy of Sciences of the United States of America Year : 2011

Fine tuning by human CD1e of lipid-specific immune responses

Federica Facciotti
  • Function : Author
Marco Cavallari
  • Function : Author
Catherine Angenieux
  • Function : Author
François Signorino-Gelo
  • Function : Author
Lena Angman
  • Function : Author
Martine Gilleron
Jacques Prandi
  • Function : Author
  • PersonId : 1386182
  • IdRef : 031516599
Germain Puzo
  • Function : Author
  • PersonId : 843230
  • IdRef : 071520600
Luigi Panza
Chengfeng Xia
  • Function : Author
Peng George Wang
  • Function : Author
Paolo Dellabona
  • Function : Author
Giulia Casorati
  • Function : Author
Steven Porcelli
  • Function : Author
  • PersonId : 1089074
Henri de La Salle
  • Function : Author
Lucia Mori
  • Function : Author
Gennaro de Libero
  • Function : Author

Abstract

CD1e is a member of the CD1 family that participates in lipid antigen presentation without interacting with the T-cell receptor. It binds lipids in lysosomes and facilitates processing of complex glycolipids, thus promoting editing of lipid antigens. We find that CD1e may positively or negatively affect lipid presentation by CD1b, CD1c, and CD1d. This effect is caused by the capacity of CD1e to facilitate rapid formation of CD1-lipid complexes, as shown for CD1d, and also to accelerate their turnover. Similar results were obtained with antigen-presenting cells from CD1e transgenic mice in which lipid complexes are assembled more efficiently and show faster turnover than in WT antigen-presenting cells. These effects maximize and temporally narrow CD1-restricted responses, as shown by reactivity to Sphingomonas paucimobilis-derived lipid antigens. CD1e is therefore an important modulator of both group 1 and group 2 CD1-restricted responses influencing the lipid antigen availability as well as the generation and persistence of CD1-lipid complexes.

Dates and versions

hal-03367125 , version 1 (06-10-2021)

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Federica Facciotti, Marco Cavallari, Catherine Angenieux, Luis Garcia-Alles, François Signorino-Gelo, et al.. Fine tuning by human CD1e of lipid-specific immune responses. Proceedings of the National Academy of Sciences of the United States of America, 2011, 108 (34), pp.14228-14233. ⟨10.1073/pnas.1108809108⟩. ⟨hal-03367125⟩
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