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Article Dans Une Revue Proceedings of the National Academy of Sciences of the United States of America Année : 2011

Fine tuning by human CD1e of lipid-specific immune responses

Federica Facciotti
  • Fonction : Auteur
Marco Cavallari
  • Fonction : Auteur
Catherine Angenieux
  • Fonction : Auteur
François Signorino-Gelo
  • Fonction : Auteur
Lena Angman
  • Fonction : Auteur
Martine Gilleron
Jacques Prandi
  • Fonction : Auteur
  • PersonId : 1386182
  • IdRef : 031516599
Germain Puzo
  • Fonction : Auteur
  • PersonId : 843230
  • IdRef : 071520600
Luigi Panza
Chengfeng Xia
  • Fonction : Auteur
Peng George Wang
  • Fonction : Auteur
Paolo Dellabona
  • Fonction : Auteur
Giulia Casorati
  • Fonction : Auteur
Steven Porcelli
  • Fonction : Auteur
  • PersonId : 1089074
Henri de La Salle
  • Fonction : Auteur
Lucia Mori
  • Fonction : Auteur
Gennaro de Libero
  • Fonction : Auteur

Résumé

CD1e is a member of the CD1 family that participates in lipid antigen presentation without interacting with the T-cell receptor. It binds lipids in lysosomes and facilitates processing of complex glycolipids, thus promoting editing of lipid antigens. We find that CD1e may positively or negatively affect lipid presentation by CD1b, CD1c, and CD1d. This effect is caused by the capacity of CD1e to facilitate rapid formation of CD1-lipid complexes, as shown for CD1d, and also to accelerate their turnover. Similar results were obtained with antigen-presenting cells from CD1e transgenic mice in which lipid complexes are assembled more efficiently and show faster turnover than in WT antigen-presenting cells. These effects maximize and temporally narrow CD1-restricted responses, as shown by reactivity to Sphingomonas paucimobilis-derived lipid antigens. CD1e is therefore an important modulator of both group 1 and group 2 CD1-restricted responses influencing the lipid antigen availability as well as the generation and persistence of CD1-lipid complexes.

Dates et versions

hal-03367125 , version 1 (06-10-2021)

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Citer

Federica Facciotti, Marco Cavallari, Catherine Angenieux, Luis Garcia-Alles, François Signorino-Gelo, et al.. Fine tuning by human CD1e of lipid-specific immune responses. Proceedings of the National Academy of Sciences of the United States of America, 2011, 108 (34), pp.14228-14233. ⟨10.1073/pnas.1108809108⟩. ⟨hal-03367125⟩
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