Biotechnological production and application of the antibiotic pimaricin: biosynthesis and its regulation - INSA Toulouse - Institut National des Sciences Appliquées de Toulouse Access content directly
Journal Articles (Review Article) Applied Microbiology and Biotechnology Year : 2016

Biotechnological production and application of the antibiotic pimaricin: biosynthesis and its regulation

Jesús Aparicio
Eva Barreales
  • Function : Author
Tamara Payero
  • Function : Author
Cláudia M Vicente
Antonio de Pedro
  • Function : Author
Javier Santos-Aberturas
  • Function : Author

Abstract

Pimaricin (natamycin) is a small polyene macrolideantibiotic used worldwide. This efficient antimycotic andantiprotozoal agent, produced by several soil bacterial speciesof the genusStreptomyces, has found application in humantherapy, in the food and beverage industries and as pesticide.It displays a broad spectrum of activity, targeting ergosterolbut bearing a particular mode of action different to other poly-ene macrolides. The biosynthesis of this only antifungal agentwith a GRAS status has been thoroughly studied, which haspermitted the manipulation of producers to engineer the bio-synthetic gene clusters in order to generate several analogues.Regulation of its production has been largely unveiled, con-stituting a model for other polyenes and setting the leads foroptimizing the production of these valuable compounds. Thisreview describes and discusses the molecular genetics, uses,mode of action, analogue generation, regulation and strategiesfor increasing pimaricin production yields.

Dates and versions

hal-02562722 , version 1 (04-05-2020)

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Jesús Aparicio, Eva Barreales, Tamara Payero, Cláudia M Vicente, Antonio de Pedro, et al.. Biotechnological production and application of the antibiotic pimaricin: biosynthesis and its regulation. Applied Microbiology and Biotechnology, 2016, 100 (1), pp.61-78. ⟨10.1007/s00253-015-7077-0⟩. ⟨hal-02562722⟩

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