Given the complexity of urban systems, it becomes essential to integrate different disciplines as well as to fit the different spatial and temporal scales of the urban planning in order to produce useful knowledge for planners. To face this challenge, the national French research project, called "multiplicities", proposes a prospective contribution to support energy-based urban renewal for European cities focused on the built urban forms and their materiality at three nested spatial scales: the urban district, the building and the building envelope. In this context, this paper focus on the methodology proposed for identifying urban typology representative cases in the city of Toulouse and for evaluating the energy demand of buildings based at three nested spatial scales simultaneously: the urban district, the building and the building envelope. This methodology allows treating with various levels of details of urban typologies: from a very detailed approach for building materials to a simplified approach for the urban neighbourhood "horizon". From a set of energy-related indicators of the urban morphology and of its materiality, three French representatives urban archetypes have provided the basis to this analytical study. A multi-scale modelling strategy is developed and integrated in an energy simulation tool. A comparative analysis of the buildings energy performance between a single scale and a multi-scale approach is drawn.