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Journal Articles Organic & Biomolecular Chemistry Year : 2005

Selective inhibition of Trypanosoma cruzi GAPDH by “bi-substrate” analogues

Abstract

A new series of “bi-substrate” analogues have been synthesized as potential inhibitors of the glyceraldehyde-3-phosphate dehydrogenase and one lead compound has been identified that inhibits the enzyme from Trypanosoma cruzi with good affinity and very high (50-fold) specificity.

Dates and versions

hal-02146253 , version 1 (03-06-2019)

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Sylvain Ladame, Régis Fauré, Colette Denier, Faouzi Lakhdar-Ghazal, Michèle Willson. Selective inhibition of Trypanosoma cruzi GAPDH by “bi-substrate” analogues. Organic & Biomolecular Chemistry, 2005, 3 (11), pp.2070. ⟨10.1039/B504703J⟩. ⟨hal-02146253⟩
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