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Monitoring of nanoparticle reactivity in solution: interaction of l -lysine and Ru nanoparticles probed by chemical shift perturbation parallels regioselective H/D exchange

Abstract : Thanks to new water-soluble Ru nanoparticles (NPs) stabilized by sulfonated NHC ligands, we demonstrate that it is possible to monitor the catalyst/substrate interaction using NMR chemical shift perturbations (CSPs), under conditions that closely resemble those applied during the enantiospecific C–H deuteration of L-lysine. Correlating the pH dependence of the interaction of L-lysine with the surface of the RuNPs and its subsequent deuteration, our study underscores the importance of oriented binding to the surface as a critical factor for H/D exchange.
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https://hal.insa-toulouse.fr/hal-02004103
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Submitted on : Friday, February 1, 2019 - 3:32:14 PM
Last modification on : Tuesday, May 26, 2020 - 1:13:04 PM

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Luis Martínez-Prieto, Edwin Baquero, Grégory Pieters, Juan Flores, Ernesto de Jesus, et al.. Monitoring of nanoparticle reactivity in solution: interaction of l -lysine and Ru nanoparticles probed by chemical shift perturbation parallels regioselective H/D exchange. Chemical Communications, Royal Society of Chemistry, 2017, 53 (43), pp.5850-5853. ⟨10.1039/c7cc02445b⟩. ⟨hal-02004103⟩

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