Synthesis of Iron Nanometallic Glasses and Their Application in Cancer Therapy by a Localized Fenton Reaction - INSA Toulouse - Institut National des Sciences Appliquées de Toulouse Access content directly
Journal Articles Angewandte Chemie International Edition Year : 2016

Synthesis of Iron Nanometallic Glasses and Their Application in Cancer Therapy by a Localized Fenton Reaction

Abstract

Metallic glasses and cancer theranostics are emerging fields that do not seem to be related to each other. Herein, we report the facile synthesis of amorphous iron nanoparticles (AFeNPs) and their superior physicochemical properties compared to their crystalline counterpart, iron nanocrystals (FeNCs). The AFeNPs can be used for cancer theranostics by inducing a Fenton reaction in the tumor by taking advantage of the mild acidity and the overproduced H2O2 in a tumor microenvironment: Ionization of the AFeNPs enables on‐demand ferrous ion release in the tumor, and subsequent H2O2 disproportionation leads to efficient .OH generation. The endogenous stimuli‐responsive .OH generation in the presence AFeNPs enables a highly specific cancer therapy without the need for external energy input.
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Dates and versions

hal-01980230 , version 1 (14-01-2019)

Identifiers

  • HAL Id : hal-01980230 , version 1

Cite

Chen Zhang, Wenbo Bu, Dalong Ni, Shenjian Zhang, Qing Li, et al.. Synthesis of Iron Nanometallic Glasses and Their Application in Cancer Therapy by a Localized Fenton Reaction. Angewandte Chemie International Edition, 2016, 55 (6), pp.2101-2106. ⟨hal-01980230⟩

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