Weak backbone CH···O=C and side chain tBu···tBu London interactions help promote helix folding of achiral NtBu peptoids

Abstract : The synthesis of all-cis amide (NtBu)-glycine oligomers up to 15 residues long by a blockwise coupling approach is reported. The structure and dynamical behavior of these peptoids have been studied by X-ray crystallography, NMR and molecular modeling. Analyses reveal that the folding of these oligomers is driven by weak CH···O=C hydrogen bonding along the peptoid backbone and London interaction between tBu···tBu side-chains.
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Submitted on : Thursday, January 3, 2019 - 10:45:55 AM
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G. Angelici, N. Bhattacharjee, O. Roy, S. Fauré, C. Didierjean, et al.. Weak backbone CH···O=C and side chain tBu···tBu London interactions help promote helix folding of achiral NtBu peptoids. Chemical Communications, Royal Society of Chemistry, 2016, 52 (24), pp.4573-4576. ⟨10.1039/c6cc00375c⟩. ⟨hal-01968717⟩

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