Weak backbone CH···O=C and side chain tBu···tBu London interactions help promote helix folding of achiral NtBu peptoids

Abstract : The synthesis of all-cis amide (NtBu)-glycine oligomers up to 15 residues long by a blockwise coupling approach is reported. The structure and dynamical behavior of these peptoids have been studied by X-ray crystallography, NMR and molecular modeling. Analyses reveal that the folding of these oligomers is driven by weak CH···O=C hydrogen bonding along the peptoid backbone and London interaction between tBu···tBu side-chains.
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Chemical Communications, Royal Society of Chemistry, 2016, 52 (24), pp.4573-4576. 〈10.1039/c6cc00375c〉
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https://hal.insa-toulouse.fr/hal-01968717
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Soumis le : jeudi 3 janvier 2019 - 10:45:55
Dernière modification le : jeudi 7 février 2019 - 17:12:39

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G. Angelici, N. Bhattacharjee, O. Roy, S. Fauré, C. Didierjean, et al.. Weak backbone CH···O=C and side chain tBu···tBu London interactions help promote helix folding of achiral NtBu peptoids. Chemical Communications, Royal Society of Chemistry, 2016, 52 (24), pp.4573-4576. 〈10.1039/c6cc00375c〉. 〈hal-01968717〉

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