Ruthenium-catalyzed hydrogen isotope exchange of C(sp 3 )–H bonds directed by a sulfur atom

Longhui Gao 1 Serge Perato 1 Sébastien Garcia-Argote 1 Céline Taglang 1 Luis Miguel Martinez-Prieto 2 Céline Chollet 1 David-Alexandre Buisson 1 Vincent Dauvois 3 Philippe Lesot 4 Bruno Chaudret 2 Bernard Rousseau 1 Sophie Feuillastre 1 Grégory Pieters 1
1 SCBM - Service de Chimie Bio-Organique et de Marquage
2 LPCNO - Laboratoire de physique et chimie des nano-objets
3 CEA Paris Saclay
4 RMO - RMN en milieu orienté
Abstract : We present here the first example of C(sp3)–H activation directed by a sulfur atom. Based on this transformation catalyzed by Ru/C, we have developed a hydrogen isotope exchange reaction for the deuterium and tritium labelling of thioether substructures in complex molecules.
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Journal articles
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https://hal.insa-toulouse.fr/hal-02000391
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Submitted on : Wednesday, January 30, 2019 - 3:33:30 PM
Last modification on : Friday, November 1, 2019 - 1:23:45 AM

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  • HAL Id : hal-02000391, version 1

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Longhui Gao, Serge Perato, Sébastien Garcia-Argote, Céline Taglang, Luis Miguel Martinez-Prieto, et al.. Ruthenium-catalyzed hydrogen isotope exchange of C(sp 3 )–H bonds directed by a sulfur atom. Chemical Communications, Royal Society of Chemistry, 2018, 54 (24), pp.2986-2989. ⟨hal-02000391⟩

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